ABSTRACT
OBJECTIVE: Health care professionals and governmental agencies are in consensus regarding contact and droplet transmission of infectious diseases. However, personal protective equipment (PPE) efficacy is not considered for aerosol or airborne transmission of infectious diseases. This review discusses the inhalation of virus-laden aerosols as a viable mechanism of transmission of various respiratory infectious diseases and PPE efficacy. METHODS: The Preferred Reporting Items for Systematic reviews, and Meta-Analysis (PRISMA) guidelines was used. RESULTS: The transmission of infectious disease is of concern for all respirable diseases discussed (SARS-CoV-1, SARS-CoV-2, MERS, influenza, and tuberculosis), and the effectiveness of facemasks is dependent on the efficiency of the filter, fit, and proper use. CONCLUSION: PPE should be the last resort in preventing the spread of infectious disease and should only be used for protection and not to control the transmission.